› 2ca7

Solution NMR

Conkunitzin-S1 Is The First Member Of A New Kunitz-Type Neurotoxin Family- Structural and Functional Characterization

Released:
DOI: 10.2210/pdb2ca7/pdb
PDB entry 2ca7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ca7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ca7 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus striatus
Primary publication:
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization.
Bayrhuber M, Vijayan V, Ferber M, Graf R, Korukottu J, Imperial J, Garrett JE, Olivera BM, Terlau H, Zweckstetter M, Becker S
J Biol Chem 280 23766-70 (2005)
PMID: 15833744

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kunitz-type conkunitzin-S1 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.94 KDa
Source organism: Conus striatus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0C1X2 (Residues: 27-86; Coverage: 100%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: MOLECULAR DYNAMICS, SIMULATED ANNEALING, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli BL21(DE3)

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Citations

14 review citations

The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms.
Fry et al. (2009)
13 more

6 mentions without citation

Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals.
Mourão et al. (2013)
5 more