› 2cdu

X-ray diffraction
1.8Å resolution

The Crystal Structure of Water-forming NAD(P)H Oxidase from Lactobacillus sanfranciscensis

Released:
DOI: 10.2210/pdb2cdu/pdb
PDB entry 2cdu coloured by chain, front view.
PDB entry 2cdu coloured by chain, side view.
PDB entry 2cdu coloured by chain, top view.
Source organism: Fructilactobacillus sanfranciscensis
Primary publication:
The crystal structure of NAD(P)H oxidase from Lactobacillus sanfranciscensis: insights into the conversion of O2 into two water molecules by the flavoenzyme.
Lountos GT, Jiang R, Wellborn WB, Thaler TL, Bommarius AS, Orville AM
Biochemistry 45 9648-59 (2006)
PMID: 16893166

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190239 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NADH oxidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 452 amino acids
Theoretical weight: 49.72 KDa
Source organism: Fructilactobacillus sanfranciscensis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9F1X5 (Residues: 1-452; Coverage: 100%)
Gene name: nox
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FAD 2 x FAD
Ligand ADP 2 x ADP
1 modified residue:
Ligand CSX 2 x CSX

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 59.636Å b: 92.644Å c: 163.465Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.223
Expression system: Escherichia coli

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Citations

2 review citations

Flavoenzymes: versatile catalysts in biosynthetic pathways.
Walsh et al. (2013)
1 more

41 mentions without citation

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Novalia Rahmawati Sianipar et al. (2023)
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