› 2ce7

X-ray diffraction
2.44Å resolution

EDTA treated

Released:
DOI: 10.2210/pdb2ce7/pdb
PDB entry 2ce7 coloured by chain, front view.
PDB entry 2ce7 coloured by chain, side view.
PDB entry 2ce7 coloured by chain, top view.
Source organism: Thermotoga maritima
Primary publication:
The molecular architecture of the metalloprotease FtsH.
Bieniossek C, Schalch T, Bumann M, Meister M, Meier R, Baumann U
Proc Natl Acad Sci U S A 103 3066-71 (2006)
PMID: 16484367

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194575 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent zinc metalloprotease FtsH Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 476 amino acids
Theoretical weight: 52.76 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9WZ49 (Residues: 147-610; Coverage: 76%)
Gene names: TM_0580, ftsH
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 6 x ZN
Ligand ADP 6 x ADP
Ligand MG 6 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P41212
Unit cell:
a: 165.092Å b: 165.092Å c: 235.322Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.222 0.269
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

26 review citations

AAA+ proteases: ATP-fueled machines of protein destruction.
Sauer et al. (2011)
25 more

9 mentions without citation

Recent Advances in Understanding the Structural and Functional Evolution of FtsH Proteases.
Yi et al. (2022)
8 more