› 2cfe

X-ray diffraction
1.5Å resolution

The 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family

Released:
DOI: 10.2210/pdb2cfe/pdb
PDB entry 2cfe coloured by chain, front view.
PDB entry 2cfe coloured by chain, side view.
PDB entry 2cfe coloured by chain, top view.
Source organism: Malassezia sympodialis
Primary publication:
Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family.
Glaser AG, Limacher A, Flückiger S, Scheynius A, Scapozza L, Crameri R
Biochem J 396 41-9 (2006)
PMID: 16483252

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 17.23 KDa
Source organism: Malassezia sympodialis
Expression system: Escherichia coli M15
UniProt:
  • Canonical: O93970 (Residues: 1-162; Coverage: 100%)
Gene name: Mal s 6
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

3 bound ligands:
Ligand ALA 1 x ALA
Ligand PRO 1 x PRO
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 71.989Å b: 71.989Å c: 106.178Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.143 0.143 0.149
Expression system: Escherichia coli M15

Quick links

Citations

16 review citations

The Malassezia genus in skin and systemic diseases.
Gaitanis et al. (2012)
15 more

7 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
6 more