› 2cfr

X-ray diffraction
2.4Å resolution

crystal structure of human pyridoxal 5'-phosphate phosphatase

Released:
DOI: 10.2210/pdb2cfr/pdb
PDB entry 2cfr coloured by chain, front view.
PDB entry 2cfr coloured by chain, side view.
PDB entry 2cfr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kang BS, Cho HJ, Kim KJ, Kwon OS

Function and Biology Details

Reactions catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188517 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chronophin Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 32.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96GD0 (Residues: 1-296; Coverage: 100%)
Gene names: CIN, PDXP, PLP, PLPP
Sequence domains:
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: P43212
Unit cell:
a: 54.3Å b: 54.3Å c: 213.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.257
Expression system: Escherichia coli BL21

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