› 2cft

X-ray diffraction
1.8Å resolution

Crystal structure of human pyridoxal 5'-phosphate phosphatase with its substrate

Released:
DOI: 10.2210/pdb2cft/pdb
PDB entry 2cft coloured by chain, front view.
PDB entry 2cft coloured by chain, side view.
PDB entry 2cft coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kang BS, Cho HJ, Kim KJ, Kwon OS

Function and Biology Details

Reactions catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188517 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chronophin Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 31.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96GD0 (Residues: 1-296; Coverage: 100%)
Gene names: CIN, PDXP, PLP, PLPP
Sequence domains:
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

2 bound ligands:
Ligand PLP 1 x PLP
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P43212
Unit cell:
a: 54.303Å b: 54.303Å c: 210.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.226
Expression system: Escherichia coli BL21

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