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› 2cg1

X-ray diffraction
1.67Å resolution

AGAO in complex with wc11b (Ru-wire inhibitor, 11-carbon linker, data set b)

Released:
DOI: 10.2210/pdb2cg1/pdb
Model geometry
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PDB entry 2cg1 coloured by chain, front view.
PDB entry 2cg1 coloured by chain, side view.
PDB entry 2cg1 coloured by chain, top view.
Source organism: Arthrobacter globiformis
Primary publication:
Enantiomer-specific binding of ruthenium(II) molecular wires by the amine oxidase of Arthrobacter globiformis.
Langley DB, Brown DE, Cheruzel LE, Contakes SM, Duff AP, Hilmer KM, Dooley DM, Gray HB, Guss JM, Freeman HC
J Am Chem Soc 130 8069-78 (2008)
PMID: 18507382

Function and Biology Details

Reaction catalysed: 
a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+).
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155528 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phenylethylamine oxidase Chain: A
Molecule details ›
Chain: A
Length: 646 amino acids
Theoretical weight: 71.76 KDa
Source organism: Arthrobacter globiformis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46881 (Residues: 3-638; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand CU 1 x CU
Ligand NA 1 x NA
Ligand 11R 1 x 11R
Ligand SO4 1 x SO4
Ligand GOL 4 x GOL
1 modified residue:
Ligand TPQ 1 x TPQ

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 157.919Å b: 63.042Å c: 92.067Å
α: 90° β: 112.19° γ: 90°
R-values:
R R work R free
0.161 0.16 0.179
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Targeting proteins with metal complexes.
Meggers E. (2009)
2 more

3 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
2 more

PDB-REDO

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