› 2cgz

X-ray diffraction
2.8Å resolution

Structure of Helix Pomatia agglutinin with Tn antigen

Released:
DOI: 10.2210/pdb2cgz/pdb
PDB entry 2cgz coloured by chain, front view.
PDB entry 2cgz coloured by chain, side view.
PDB entry 2cgz coloured by chain, top view.
Source organism: Helix pomatia
Primary publication:
Structural basis for recognition of breast and colon cancer epitopes Tn antigen and Forssman disaccharide by Helix pomatia lectin.
Lescar J, Sanchez JF, Audfray A, Coll JL, Breton C, Mitchell EP, Imberty A
Glycobiology 17 1077-83 (2007)
PMID: 17652409

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173384 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
H-type lectin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.34 KDa
Source organism: Helix pomatia
UniProt:
  • Canonical: Q2F1K8 (Residues: 21-121; Coverage: 99%)
Gene name: hpa
Sequence domains: H-type lectin domain
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand SER 1 x SER
Ligand A2G 1 x A2G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P6322
Unit cell:
a: 62.1Å b: 62.1Å c: 106.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.242 0.29

Quick links

Citations

4 review citations

The Tn antigen-structural simplicity and biological complexity.
Ju et al. (2011)
3 more

3 mentions without citation

Structure and Analysis of R1 and R2 Pyocin Receptor-Binding Fibers.
Buth et al. (2018)
2 more