› 2ch8

X-ray diffraction
2.3Å resolution

Structure of the Epstein-Barr Virus Oncogene BARF1

Released:
DOI: 10.2210/pdb2ch8/pdb
PDB entry 2ch8 coloured by chain, front view.
PDB entry 2ch8 coloured by chain, side view.
PDB entry 2ch8 coloured by chain, top view.
Source organism: Human gammaherpesvirus 4
Primary publication:
Structure of the Epstein-Barr virus oncogene BARF1.
Tarbouriech N, Ruggiero F, de Turenne-Tessier M, Ooka T, Burmeister WP
J Mol Biol 359 667-78 (2006)
PMID: 16647084

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136664 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Secreted protein BARF1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 201 amino acids
Theoretical weight: 22.47 KDa
Source organism: Human gammaherpesvirus 4
Expression system: Homo sapiens
UniProt:
  • Canonical: P03228 (Residues: 21-221; Coverage: 100%)
Gene name: BARF1
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
1 bound ligand:
Ligand PT 12 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: R3
Unit cell:
a: 179.245Å b: 179.245Å c: 95.72Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.174 0.233
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Nasopharyngeal carcinoma: molecular biomarker discovery and progress.
Cho WC. (2007)
10 more

2 mentions without citation

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Shim et al. (2012)
1 more