› 2cm4

X-ray diffraction
1.9Å resolution

The complement inhibitor OmCI in complex with ricinoleic acid

Released:
DOI: 10.2210/pdb2cm4/pdb
PDB entry 2cm4 coloured by chain, front view.
PDB entry 2cm4 coloured by chain, side view.
PDB entry 2cm4 coloured by chain, top view.
Source organism: Ornithodoros moubata
Primary publication:
The structure of OMCI, a novel lipocalin inhibitor of the complement system.
Roversi P, Lissina O, Johnson S, Ahmat N, Paesen GC, Ploss K, Boland W, Nunn MA, Lea SM
J Mol Biol 369 784-93 (2007)
PMID: 17445829

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement inhibitor Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 16.83 KDa
Source organism: Ornithodoros moubata
Expression system: Ogataea methanolica
UniProt:
  • Canonical: Q5YD59 (Residues: 19-168; Coverage: 100%)
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand ACT 1 x ACT
Ligand RCL 1 x RCL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 45.17Å b: 55.52Å c: 60.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 not available
Expression system: Ogataea methanolica

Quick links

Citations

11 review citations

Complement evasion by human pathogens.
Lambris et al. (2008)
10 more

6 mentions without citation

Structure and mechanism in salivary proteins from blood-feeding arthropods.
Andersen JF. (2010)
5 more