› 2cm5

X-ray diffraction
1.28Å resolution

crystal structure of the C2B domain of rabphilin

Released:
DOI: 10.2210/pdb2cm5/pdb
PDB entry 2cm5 coloured by chain, front view.
PDB entry 2cm5 coloured by chain, side view.
PDB entry 2cm5 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A.
Montaville P, Schlicker C, Leonov A, Zweckstetter M, Sheldrick GM, Becker S
J Biol Chem 282 5015-5025 (2007)
PMID: 17166855

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rabphilin-3A Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 19.3 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47709 (Residues: 519-684; Coverage: 24%)
Gene name: Rph3a
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 53.898Å b: 60.043Å c: 41.928Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 not available 0.194
Expression system: Escherichia coli

Quick links

Citations

2 review citations

DOC2B, C2 domains, and calcium: A tale of intricate interactions.
Friedrich et al. (2010)
1 more

4 mentions without citation

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
Stanic et al. (2015)
3 more