› 2ct0

Solution NMR

Solution structure of the RING domain of the Non-SMC element 1 protein

Released:
DOI: 10.2210/pdb2ct0/pdb
PDB entry 2ct0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ct0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ct0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Miyamoto K, Sato M, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186728 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural maintenance of chromosomes element 1 homolog Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8WV22 (Residues: 181-241; Coverage: 23%)
Gene names: HSPC333, HSPC337, NSMCE1
Sequence domains: RING-like domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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