› 2cw9

X-ray diffraction
1.9Å resolution

Crystal structure of human Tim44 C-terminal domain

Released:
DOI: 10.2210/pdb2cw9/pdb
PDB entry 2cw9 coloured by chain, front view.
PDB entry 2cw9 coloured by chain, side view.
PDB entry 2cw9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form.
Handa N, Kishishita S, Morita S, Akasaka R, Jin Z, Chrzas J, Chen L, Liu ZJ, Wang BC, Sugano S, Tanaka A, Terada T, Shirouzu M, Yokoyama S
Acta Crystallogr D Biol Crystallogr 63 1225-34 (2007)
PMID: 18084070

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial import inner membrane translocase subunit TIM44 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43615 (Residues: 266-452; Coverage: 41%)
Gene names: MIMT44, TIM44, TIMM44
Sequence domains: Tim44-like domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

1 bound ligand:
Ligand 1PE 2 x 1PE
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6522
Unit cell:
a: 108.119Å b: 108.119Å c: 114.056Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.218 0.221
Expression system: Not provided

Quick links

Citations

3 review citations

The process of mammalian mitochondrial protein synthesis.
Mai et al. (2017)
2 more

6 mentions without citation

Transplanting supersites of HIV-1 vulnerability.
Zhou et al. (2014)
5 more