› 2cyg

X-ray diffraction
1.45Å resolution

Crystal structure at 1.45- resolution of the major allergen endo-beta-1,3-glucanase of banana as a molecular basis for the latex-fruit syndrome

Released:
DOI: 10.2210/pdb2cyg/pdb
PDB entry 2cyg coloured by chain, front view.
PDB entry 2cyg coloured by chain, side view.
PDB entry 2cyg coloured by chain, top view.
Source organism: Musa acuminata
Primary publication:
Crystal structure at 1.45-A resolution of the major allergen endo-beta-1,3-glucanase of banana as a molecular basis for the latex-fruit syndrome.
Receveur-Bréchot V, Czjzek M, Barre A, Roussel A, Peumans WJ, Van Damme EJ, Rougé P
Proteins 63 235-42 (2006)
PMID: 16421930

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127630 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucan endo-1,3-beta-glucosidase Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 33.44 KDa
Source organism: Musa acuminata
UniProt:
  • Canonical: O22317 (Residues: 29-340; Coverage: 100%)
Gene name: BANGLUC
Sequence domains: Glycosyl hydrolases family 17
Structure domains: Glycosidases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 48.27Å b: 53.93Å c: 113.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.157 0.179

Quick links

Citations

1 review citation

Mapping of IgE-binding epitopes on the major latex allergen Hev b 2 and the cross-reacting 1,3beta-glucanase fruit allergens as a molecular basis for the latex-fruit syndrome.
Barre et al. (2009)
14 other articles

9 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
8 more