› 2d2r

X-ray diffraction
1.88Å resolution

Crystal structure of Helicobacter pylori Undecaprenyl Pyrophosphate Synthase

Released:
DOI: 10.2210/pdb2d2r/pdb
PDB entry 2d2r coloured by chain, front view.
PDB entry 2d2r coloured by chain, side view.
PDB entry 2d2r coloured by chain, top view.
Source organism: Helicobacter pylori
Primary publication:
Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases.
Kuo CJ, Guo RT, Lu IL, Liu HG, Wu SY, Ko TP, Wang AH, Liang PH
J Biomed Biotechnol 2008 841312 (2008)
PMID: 18382620

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157378 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isoprenyl transferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 245 amino acids
Theoretical weight: 28.58 KDa
Source organism: Helicobacter pylori
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55984 (Residues: 1-233; Coverage: 100%)
Gene names: HP_1221, uppS
Sequence domains: Putative undecaprenyl diphosphate synthase
Structure domains: Decaprenyl diphosphate synthase-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL17B2
Spacegroup: P212121
Unit cell:
a: 49.63Å b: 58.914Å c: 153.425Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Anti-infectious agents against MRSA.
Koyama et al. (2012)
2 more

1 mention without citation

Crystallization and preliminary X-ray diffraction analysis of cyclolavandulyl diphosphate synthase, a new member of the cis-isoprenyl diphosphate synthase superfamily.
Tomita et al. (2014)