› 2ddi

Solution NMR

NMR structure of the second Kunitz domain of human WFIKKN1

Released:
DOI: 10.2210/pdb2ddi/pdb
PDB entry 2ddi coloured by chain, ensemble of 20 models, front view.
PDB entry 2ddi coloured by chain, ensemble of 20 models, side view.
PDB entry 2ddi coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein.
Liepinsh E, Nagy A, Trexler M, Patthy L, Otting G
J Biomol NMR 35 73-8 (2006)
PMID: 16791741

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188653 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 70 amino acids
Theoretical weight: 7.88 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q96NZ8 (Residues: 357-411; Coverage: 10%)
Gene names: C16orf12, GASP2, PSEC0040, WFIKKN, WFIKKN1
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Komagataella pastoris

Quick links

Citations

3 review citations

Structural biology of the TGFβ family.
Goebel et al. (2019)
2 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)