› 2des

X-ray diffraction
1.5Å resolution

INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)

Released:
DOI: 10.2210/pdb2des/pdb
PDB entry 2des coloured by chain, front view.
PDB entry 2des coloured by chain, side view.
PDB entry 2des coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Interactions between morpholinyl anthracyclines and DNA. The crystal structure of a morpholino doxorubicin bound to d(CGTACG).
Cirilli M, Bachechi F, Ughetto G, Colonna FP, Capobianco ML
J Mol Biol 230 878-89 (1993)
PMID: 8478940

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115170 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand DMM 2 x DMM
Ligand NA 2 x NA
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 18.01Å b: 18.83Å c: 26.75Å
α: 92.6° β: 100.5° γ: 94.9°
R-values:
R R work R free
0.192 not available not available
Expression system: Not provided

Quick links

Citations

14 citation in other articles

Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate.
Choi et al. (2010)
13 more

77 mentions without citation

Breast Cancer Stem-Like Cells in Drug Resistance: A Review of Mechanisms and Novel Therapeutic Strategies to Overcome Drug Resistance.
Saha et al. (2022)
76 more