› 2dh2

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140013 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amino acid transporter heavy chain SLC3A2 Chain: A
Molecule details ›
Chain: A
Length: 424 amino acids
Theoretical weight: 46.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08195 (Residues: 212-630; Coverage: 67%)
Gene names: MDU1, SLC3A2
Sequence domains: Alpha amylase, catalytic domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21
Unit cell:
a: 39.674Å b: 67.846Å c: 73.949Å
α: 90° β: 98.49° γ: 90°
R-values:
R R work R free
0.178 0.175 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

20 review citations

The SLC3 and SLC7 families of amino acid transporters.
Fotiadis et al. (2013)
19 more

12 mentions without citation

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Singh et al. (2018)
11 more