› 2dk4

Solution NMR

Solution structure of Splicing Factor Motif in Pre-mRNA splicing factor 18 (hPRP18)

Released:
DOI: 10.2210/pdb2dk4/pdb
PDB entry 2dk4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2dk4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2dk4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the splicing factor motif of the human Prp18 protein.
He F, Inoue M, Kigawa T, Takahashi M, Kuwasako K, Tsuda K, Kobayashi N, Terada T, Shirouzu M, Güntert P, Yokoyama S, Muto Y
Proteins 80 968-74 (2012)
PMID: 22213562

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189236 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pre-mRNA-splicing factor 18 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.39 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: Q99633 (Residues: 60-122; Coverage: 18%)
Gene names: HPRP18, PRPF18
Sequence domains: pre-mRNA processing factor 4 (PRP4) like
Structure domains: Pre-mRNA processing factor 4 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Cell free synthesis

Quick links

Citations

3 citation in other articles

Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity.
Minakuchi et al. (2017)
2 more

3 mentions without citation

Detailed close-ups and the big picture of spliceosomes.
Jurica MS. (2008)
2 more