› 2dmv

Solution NMR

Solution structure of the second ww domain of Itchy homolog E3 ubiquitin protein ligase (Itch)

Released:
DOI: 10.2210/pdb2dmv/pdb
PDB entry 2dmv coloured by chain, ensemble of 20 models, front view.
PDB entry 2dmv coloured by chain, ensemble of 20 models, side view.
PDB entry 2dmv coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Ohnishi S, Paakkonen K, Tochio N, Tomizawa T, Koshiba S, Inoue M, Guntert P, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase Itchy homolog Chain: A
Molecule details ›
Chain: A
Length: 43 amino acids
Theoretical weight: 4.72 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: Q96J02 (Residues: 328-357; Coverage: 3%)
Gene name: ITCH
Sequence domains: WW domain
Structure domains: Ubiquitin Ligase Nedd4; Chain: W;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Cell free synthesis

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