› 2dob

X-ray diffraction
2Å resolution

Crystal Structure of Human Saposin A

Released:
DOI: 10.2210/pdb2dob/pdb
PDB entry 2dob coloured by chain, front view.
PDB entry 2dob coloured by chain, side view.
PDB entry 2dob coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of saposins A and C.
Ahn VE, Leyko P, Alattia JR, Chen L, Privé GG
Protein Sci 15 1849-57 (2006)
PMID: 16823039

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-139656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Saposin-A Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07602 (Residues: 58-140; Coverage: 16%)
Gene names: GLBA, PSAP, SAP1
Sequence domains:
Structure domains: Saposin-like

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P21212
Unit cell:
a: 45.68Å b: 50.04Å c: 33.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.218 0.267
Expression system: Escherichia coli

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Citations

13 review citations

Lysosomal degradation of membrane lipids.
Kolter et al. (2010)
12 more

17 mentions without citation

Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.
Ruiz-Canada et al. (2009)
16 more