› 2dw2

X-ray diffraction
2.7Å resolution

Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)

Released:
DOI: 10.2210/pdb2dw2/pdb
PDB entry 2dw2 coloured by chain, front view.
PDB entry 2dw2 coloured by chain, side view.
PDB entry 2dw2 coloured by chain, top view.
Source organism: Crotalus atrox
Primary publication:
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins.
Igarashi T, Araki S, Mori H, Takeda S
FEBS Lett 581 2416-22 (2007)
PMID: 17485084

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187443 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Zinc metalloproteinase-disintegrin-like VAP2B Chains: A, B
Molecule details ›
Chains: A, B
Length: 419 amino acids
Theoretical weight: 46.91 KDa
Source organism: Crotalus atrox
UniProt:
  • Canonical: Q90282 (Residues: 191-609; Coverage: 71%)
Sequence domains:
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
2 bound ligands:
Ligand ZN 2 x ZN
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 220.742Å b: 79.475Å c: 58.69Å
α: 90° β: 91.73° γ: 90°
R-values:
R R work R free
0.199 0.199 0.26

Quick links

Citations

14 review citations

The ADAM metalloproteinases.
Edwards et al. (2008)
13 more

5 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
4 more