› 2dwv

Solution NMR

Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)

Released:
DOI: 10.2210/pdb2dwv/pdb
PDB entry 2dwv coloured by chain, ensemble of 20 models, front view.
PDB entry 2dwv coloured by chain, ensemble of 20 models, side view.
PDB entry 2dwv coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form.
Ohnishi S, Güntert P, Koshiba S, Tomizawa T, Akasaka R, Tochio N, Sato M, Inoue M, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yokoyama S
FEBS Lett 581 462-8 (2007)
PMID: 17239860

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein salvador homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 49 amino acids
Theoretical weight: 5.3 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q8VEB2 (Residues: 231-266; Coverage: 9%)
Gene names: Sav1, Ww45, Wwp3
Structure domains: Ubiquitin Ligase Nedd4; Chain: W;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

9 review citations

Modularity in the Hippo signaling pathway.
Sudol et al. (2010)
8 more

5 mentions without citation

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Bae et al. (2017)
4 more