› 2dx0

X-ray diffraction
2.5Å resolution

Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2

Released:
DOI: 10.2210/pdb2dx0/pdb
PDB entry 2dx0 coloured by chain, front view.
PDB entry 2dx0 coloured by chain, side view.
PDB entry 2dx0 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Handa N, Takagi T, Murayama K, Terada T, Shirouzu M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-183983 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 15.68 KDa
Source organism: Mus musculus
Expression system: Cell-free protein synthesis
UniProt:
  • Canonical: Q8CIH5 (Residues: 516-640; Coverage: 10%)
Gene name: Plcg2
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P41212
Unit cell:
a: 80.905Å b: 80.905Å c: 133.734Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.262
Expression system: Cell-free protein synthesis

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