› 2dyp

X-ray diffraction
2.5Å resolution

Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G

Released:
DOI: 10.2210/pdb2dyp/pdb
PDB entry 2dyp coloured by chain, front view.
PDB entry 2dyp coloured by chain, side view.
PDB entry 2dyp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).
Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, Kato K, Kohda D, Maenaka K
Proc Natl Acad Sci U S A 103 16412-7 (2006)
PMID: 17056715

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-147613 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class I histocompatibility antigen, alpha chain G Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 32.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17693 (Residues: 25-300; Coverage: 88%)
Gene names: HLA-6.0, HLA-G, HLAG
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Histone H2AX Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16104 (Residues: 78-86; Coverage: 6%)
Gene names: H2AFX, H2AX
Leukocyte immunoglobulin-like receptor subfamily B member 2 Chain: D
Molecule details ›
Chain: D
Length: 196 amino acids
Theoretical weight: 21.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N423 (Residues: 24-219; Coverage: 34%)
Gene names: ILT4, LILRB2, LIR2, MIR10
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P3121
Unit cell:
a: 81.4Å b: 81.4Å c: 186.733Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.233 0.278
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

61 review citations

Activating and inhibitory receptors of natural killer cells.
Pegram et al. (2011)
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13 mentions without citation

Structural insights into activation of antiviral NK cell responses.
Finton et al. (2012)
12 more