› 2e4w

X-ray diffraction
2.4Å resolution

Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with 1S,3S-ACPD

Released:
DOI: 10.2210/pdb2e4w/pdb
PDB entry 2e4w coloured by chain, front view.
PDB entry 2e4w coloured by chain, side view.
PDB entry 2e4w coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors.
Muto T, Tsuchiya D, Morikawa K, Jingami H
Proc Natl Acad Sci U S A 104 3759-64 (2007)
PMID: 17360426

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 555 amino acids
Theoretical weight: 63.12 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P31422 (Residues: 25-575; Coverage: 64%)
Gene names: Gprc1c, Grm3, Mglur3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand C5A 2 x C5A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21
Unit cell:
a: 83.739Å b: 97.313Å c: 107.814Å
α: 90° β: 92.94° γ: 90°
R-values:
R R work R free
0.238 0.236 0.267
Expression system: Trichoplusia ni

Quick links

Citations

69 review citations

Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Niswender et al. (2010)
68 more

9 mentions without citation

Metabotropic glutamate receptors: from the workbench to the bedside.
Nicoletti et al. (2011)
8 more