› 2e7u

X-ray diffraction
1.9Å resolution

Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from Thermus thermophilus HB8

Released:
DOI: 10.2210/pdb2e7u/pdb
PDB entry 2e7u coloured by chain, front view.
PDB entry 2e7u coloured by chain, side view.
PDB entry 2e7u coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Entry authors: Mizutani H, Kunishima N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
(S)-4-amino-5-oxopentanoate = 5-aminolevulinate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate-1-semialdehyde 2,1-aminomutase Chain: A
Molecule details ›
Chain: A
Length: 424 amino acids
Theoretical weight: 46.09 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5SJS4 (Residues: 1-424; Coverage: 100%)
Gene names: TTHA0934, hemL
Sequence domains: Aminotransferase class-III
Structure domains:

Ligands and Environments


Cofactor: Ligand PMP 1 x PMP
2 bound ligands:
Ligand NA 2 x NA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: R32
Unit cell:
a: 180.674Å b: 180.674Å c: 117.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.18 0.198
Expression system: Escherichia coli BL21(DE3)

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