› 2ef5

X-ray diffraction
2Å resolution

Crystal structure of the arginase from thermus thermophilus

Released:
DOI: 10.2210/pdb2ef5/pdb
PDB entry 2ef5 coloured by chain, front view.
PDB entry 2ef5 coloured by chain, side view.
PDB entry 2ef5 coloured by chain, top view.
Source organism: Thermus thermophilus
Entry authors: Kumarevel TS, Karthe P, Kuramitsu S, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177938 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase Chains: A, B, D, E, F, G
Molecule details ›
Chains: A, B, D, E, F, G
Length: 290 amino acids
Theoretical weight: 31.14 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5SI78 (Residues: 2-291; Coverage: 100%)
Gene name: TTHA1496
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

3 bound ligands:
Ligand MN 12 x MN
Ligand GAI 6 x GAI
Ligand LYS 6 x LYS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: C2
Unit cell:
a: 150.795Å b: 97.478Å c: 126.463Å
α: 90° β: 108.66° γ: 90°
R-values:
R R work R free
0.233 0.233 0.236
Expression system: Escherichia coli

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