› 2egk

X-ray diffraction
2.85Å resolution

Crystal Structure of Tamalin PDZ-Intrinsic Ligand Fusion Protein

Released:
DOI: 10.2210/pdb2egk/pdb
PDB entry 2egk coloured by chain, front view.
PDB entry 2egk coloured by chain, side view.
PDB entry 2egk coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.
Sugi T, Oyama T, Muto T, Nakanishi S, Morikawa K, Jingami H
EMBO J 26 2192-205 (2007)
PMID: 17396155

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-185901 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
General receptor for phosphoinositides 1-associated scaffold protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 101 amino acids
Theoretical weight: 11.28 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8R4T5 (Residues: 96-189; Coverage: 24%)
Gene names: Grasp, Tamalin
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P212121
Unit cell:
a: 48.56Å b: 114.07Å c: 125.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.269 0.291
Expression system: Escherichia coli BL21

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Citations

14 review citations

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
Feng et al. (2009)
13 more

2 mentions without citation

Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.
Sugi et al. (2007)
1 more