› 2eja

X-ray diffraction
1.9Å resolution

Crystal Structure Of Uroporphyrinogen Decarboxylase From Aquifex aeolicus

Released:
DOI: 10.2210/pdb2eja/pdb
PDB entry 2eja coloured by chain, front view.
PDB entry 2eja coloured by chain, side view.
PDB entry 2eja coloured by chain, top view.
Source organism: Aquifex aeolicus
Entry authors: Bagautdinov B, Kunishima N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Uroporphyrinogen III = coproporphyrinogen + 4 CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uroporphyrinogen decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 338 amino acids
Theoretical weight: 38.73 KDa
Source organism: Aquifex aeolicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O66667 (Residues: 1-338; Coverage: 100%)
Gene names: aq_334, hemE
Sequence domains: Uroporphyrinogen decarboxylase (URO-D)
Structure domains: TIM Barrel

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 65.473Å b: 80.403Å c: 128.999Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.27
Expression system: Escherichia coli

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