› 2eq6

X-ray diffraction
1.6Å resolution

Crystal structure of lipoamide dehydrogenase from thermus thermophilus HB8

Released:
DOI: 10.2210/pdb2eq6/pdb
PDB entry 2eq6 coloured by chain, front view.
PDB entry 2eq6 coloured by chain, side view.
PDB entry 2eq6 coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Entry authors: Nakai T, Kamiya N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrolipoyl dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 464 amino acids
Theoretical weight: 49.15 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5SLR0 (Residues: 1-464; Coverage: 100%)
Gene name: TTHA0233
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44B2
Spacegroup: P1
Unit cell:
a: 61.323Å b: 62.683Å c: 73.562Å
α: 93.26° β: 107.39° γ: 108.71°
R-values:
R R work R free
0.199 0.199 0.219
Expression system: Escherichia coli

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