› 2err

Solution NMR

NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU

Released:
DOI: 10.2210/pdb2err/pdb
PDB entry 2err coloured by chain, ensemble of 30 models, front view.
PDB entry 2err coloured by chain, ensemble of 30 models, side view.
PDB entry 2err coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of RNA recognition by the human alternative splicing factor Fox-1.
Auweter SD, Fasan R, Reymond L, Underwood JG, Black DL, Pitsch S, Allain FH
EMBO J 25 163-73 (2006)
PMID: 16362037

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192650 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
RNA binding protein fox-1 homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NWB1 (Residues: 109-196; Coverage: 22%)
Gene names: A2BP, A2BP1, FOX1, HRNBP1, RBFOX1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
UGCAUGU Chain: B
Molecule details ›
Chain: B
Length: 7 nucleotides
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

22 review citations

RNA-binding proteins: modular design for efficient function.
Lunde et al. (2007)
21 more

25 mentions without citation

Sequence-specific binding of single-stranded RNA: is there a code for recognition?
Auweter et al. (2006)
24 more