› 2et0

X-ray diffraction
1.7Å resolution

The structure of a three-way DNA junction in complex with a metallo-supramolecular helicate reveals a new target for drugs

Released:
DOI: 10.2210/pdb2et0/pdb
PDB entry 2et0 coloured by chain, front view.
PDB entry 2et0 coloured by chain, side view.
PDB entry 2et0 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Molecular recognition of a three-way DNA junction by a metallosupramolecular helicate.
Oleksy A, Blanco AG, Boer R, Usón I, Aymamí J, Rodger A, Hannon MJ, Coll M, Coll M
Angew Chem Int Ed Engl 45 1227-31 (2006)
PMID: 16463312

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115213 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*TP*AP*CP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand FE2 6 x FE2
Ligand NPM 5 x NPM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM16, ESRF BEAMLINE ID14-2
Spacegroup: P4132
Unit cell:
a: 71.2Å b: 71.2Å c: 71.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.256 0.291
Expression system: Not provided

Quick links

Citations

18 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
17 more

9 mentions without citation

New trends for metal complexes with anticancer activity.
Bruijnincx et al. (2008)
8 more