› 2eum

X-ray diffraction
2.3Å resolution

Crystal structure of human Glycolipid Transfer Protein complexed with 8:0 Lactosylceramide

Released:
DOI: 10.2210/pdb2eum/pdb
PDB entry 2eum coloured by chain, front view.
PDB entry 2eum coloured by chain, side view.
PDB entry 2eum coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.
Malinina L, Malakhova ML, Kanack AT, Lu M, Abagyan R, Brown RE, Patel DJ
PLoS Biol 4 e362 (2006)
PMID: 17105344

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192739 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycolipid transfer protein Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZD2 (Residues: 1-209; Coverage: 100%)
Gene name: GLTP
Sequence domains: Glycolipid transfer protein (GLTP)
Structure domains: Glycolipid transfer protein

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
4 bound ligands:
Ligand SPH 1 x SPH
Ligand OCA 1 x OCA
Ligand OCT 1 x OCT
Ligand D10 1 x D10
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2
Unit cell:
a: 75.509Å b: 49.264Å c: 68.66Å
α: 90° β: 122.57° γ: 90°
R-values:
R R work R free
0.187 0.184 0.25
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Membranes in balance: mechanisms of sphingolipid homeostasis.
Breslow et al. (2010)
11 more

2 mentions without citation

The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.
Malinina et al. (2006)
1 more