› 2ew4

Solution NMR

Solution structure of MrIA

Released:
DOI: 10.2210/pdb2ew4/pdb
PDB entry 2ew4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ew4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ew4 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus marmoreus
Primary publication:
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter.
Nilsson KP, Lovelace ES, Caesar CE, Tynngård N, Alewood PF, Johansson HM, Sharpe IA, Lewis RJ, Daly NL, Craik DJ
Biopolymers 80 815-23 (2005)
PMID: 15931669

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157729 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chi-conotoxin MrIA Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.41 KDa
Source organism: Conus marmoreus
Expression system: Not provided
UniProt:
  • Canonical: P58808 (Residues: 49-61; Coverage: 31%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 1 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

3 review citations

Conus venom peptide pharmacology.
Lewis et al. (2012)
2 more

5 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
4 more