› 2ezw

Solution NMR

Solution structure of the docking and dimerization domain of the type I alpha regulatory subunit of protein kinase A (RIalpha D/D)

Released:
DOI: 10.2210/pdb2ezw/pdb
PDB entry 2ezw coloured by chain, ensemble of 18 models, front view.
PDB entry 2ezw coloured by chain, ensemble of 18 models, side view.
PDB entry 2ezw coloured by chain, ensemble of 18 models, top view.
Source organism: Bos taurus
Primary publication:
Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform.
Banky P, Roy M, Newlon MG, Morikis D, Haste NM, Taylor SS, Jennings PA
J Mol Biol 330 1117-29 (2003)
PMID: 12860132

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132582 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed Chains: A, B
Molecule details ›
Chains: A, B
Length: 50 amino acids
Theoretical weight: 6.01 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00514 (Residues: 13-62; Coverage: 13%)
Gene name: PRKAR1A
Sequence domains: Regulatory subunit of type II PKA R-subunit
Structure domains: cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.
Taylor et al. (2008)
9 more