› 2f4s

X-ray diffraction
2.8Å resolution

A-site RNA in complex with neamine

Released:
DOI: 10.2210/pdb2f4s/pdb
PDB entry 2f4s coloured by chain, front view.
PDB entry 2f4s coloured by chain, side view.
PDB entry 2f4s coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site.
Murray JB, Meroueh SO, Russell RJ, Lentzen G, Haddad J, Mobashery S
Chem Biol 13 129-38 (2006)
PMID: 16492561

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196344 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 21 nucleotides
Theoretical weight: 6.74 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand XXX 1 x XXX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 33.055Å b: 47.31Å c: 85.343Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.249
Expression system: Not provided

Quick links

Citations

5 review citations

Molecular dynamics simulations of RNA: an in silico single molecule approach.
McDowell et al. (2007)
4 more

1 mention without citation

RLDOCK method for predicting RNA-small molecule binding modes.
Jiang et al. (2022)