2f5b

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF FAB' FROM THE HIV-1 NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH ITS GP41 EPITOPE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-212452 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
PROTEIN (ANTIBODY 2F5 (LIGHT CHAIN)) Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
PROTEIN (ANTIBODY 2F5 (HEAVY CHAIN)) Chain: H
Molecule details ›
Chain: H
Length: 235 amino acids
Theoretical weight: 24.96 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Transmembrane protein gp41 Chain: P
Molecule details ›
Chain: P
Length: 7 amino acids
Theoretical weight: 849 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q75760 (Residues: 653-659; Coverage: 1%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P212121
Unit cell:
a: 58Å b: 65Å c: 175.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.232 0.258
Expression system: Not provided