› 2f6n

X-ray diffraction
2Å resolution

Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the free form

Released:
DOI: 10.2210/pdb2f6n/pdb
PDB entry 2f6n coloured by chain, front view.
PDB entry 2f6n coloured by chain, side view.
PDB entry 2f6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.
Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ
Nature 442 91-5 (2006)
PMID: 16728978

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171407 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleosome-remodeling factor subunit BPTF Chains: A, B
Molecule details ›
Chains: A, B
Length: 174 amino acids
Theoretical weight: 20.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12830 (Residues: 2865-3033; Coverage: 6%)
Gene names: BPTF, FAC1, FALZ
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21212
Unit cell:
a: 85.144Å b: 144.894Å c: 38.315Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.234
Expression system: Escherichia coli

Quick links

Citations

147 review citations

The epigenomics of cancer.
Jones et al. (2007)
146 more

6 mentions without citation

Catching Nucleosome by Its Decorated Tails Determines Its Functional States.
Sehrawat et al. (2022)
5 more