› 2f6q

X-ray diffraction
1.95Å resolution

The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)

Released:
DOI: 10.2210/pdb2f6q/pdb
PDB entry 2f6q coloured by chain, front view.
PDB entry 2f6q coloured by chain, side view.
PDB entry 2f6q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Turnbull A, Lukacik P, Shafqat N, Smee C, Berridge G, Guo K, von Delft F, Weigelt J, Sundstrom M, Arrowsmith C, Edwards A, Gileadi O, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131004 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enoyl-CoA delta isomerase 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 280 amino acids
Theoretical weight: 31.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75521 (Residues: 137-394; Coverage: 66%)
Gene names: DRS1, ECI2, HCA88, PECI
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand TRS 1 x TRS
1 modified residue:
Ligand MSE 21 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 46.931Å b: 123.196Å c: 128.133Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.213 0.257
Expression system: Escherichia coli

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