› 2f9t

X-ray diffraction
2.2Å resolution

Structure of the type III CoaA from Pseudomonas aeruginosa

Released:
DOI: 10.2210/pdb2f9t/pdb
PDB entry 2f9t coloured by chain, front view.
PDB entry 2f9t coloured by chain, side view.
PDB entry 2f9t coloured by chain, top view.
Source organism: Pseudomonas aeruginosa PAO1
Primary publication:
Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties.
Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R
Structure 14 1251-61 (2006)
PMID: 16905099

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191054 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Type III pantothenate kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 29.62 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HWC1 (Residues: 1-248; Coverage: 100%)
Gene names: PA4279, coaA, coaX
Sequence domains: Type III pantothenate kinase
Structure domains: Nucleotidyltransferase; domain 5

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P41212
Unit cell:
a: 91.25Å b: 91.25Å c: 179.201Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.268
Expression system: Escherichia coli

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Citations

4 review citations

Coenzyme A biosynthesis: an antimicrobial drug target.
Spry et al. (2008)
3 more

1 mention without citation

Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK).
Shapiro et al. (2019)