› 2fbe

X-ray diffraction
2.52Å resolution

Crystal Structure of the PRYSPRY-domain

Released:
DOI: 10.2210/pdb2fbe/pdb
PDB entry 2fbe coloured by chain, front view.
PDB entry 2fbe coloured by chain, side view.
PDB entry 2fbe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.
Grütter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grütter MG
FEBS Lett 580 99-106 (2006)
PMID: 16364311

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108003 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ret finger protein-like 4A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 201 amino acids
Theoretical weight: 22.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A6NLU0 (Residues: 94-287; Coverage: 68%)
Gene names: RFPL4, RFPL4A, RNF210
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P4122
Unit cell:
a: 77.22Å b: 77.22Å c: 297.299Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Inflammatory caspases and inflammasomes: master switches of inflammation.
Martinon et al. (2007)
15 more

10 mentions without citation

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.
D'Cruz et al. (2013)
9 more