› 2fim

X-ray diffraction
1.9Å resolution

Structure of the C-terminal domain of Human Tubby-like protein 1

Released:
DOI: 10.2210/pdb2fim/pdb
PDB entry 2fim coloured by chain, front view.
PDB entry 2fim coloured by chain, side view.
PDB entry 2fim coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Hallberg BM, Ogg D, Arrowsmith C, Berglund H, Edwards A, Ehn M, Flodin S, Graslund S, Hammarstrom M, Hogbom M, Holmberg-Schiavone L, Kotenyova T, Kursula P, Nilsson-Ehle P, Nordlund P, Nyman T, Sagemark J, Stenmark P, Sundstrom M, Thorsell AG, Van Den Berg S, Weigelt J, Persson C

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126229 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tubby-related protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00294 (Residues: 290-542; Coverage: 47%)
Gene names: TUBL1, TULP1
Sequence domains: Tub family
Structure domains: Tubby Protein; Chain A

Ligands and Environments

2 bound ligands:
Ligand 3DP 1 x 3DP
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 55.96Å b: 85.15Å c: 58.79Å
α: 90° β: 92.93° γ: 90°
R-values:
R R work R free
0.201 0.199 0.235
Expression system: Escherichia coli BL21(DE3)

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