› 2fk4

Solution NMR

Solution structure of the C-terminal zinc binding domain of the HPV16 E6 oncoprotein

Released:
DOI: 10.2210/pdb2fk4/pdb
PDB entry 2fk4 coloured by chain, ensemble of 10 models, front view.
PDB entry 2fk4 coloured by chain, ensemble of 10 models, side view.
PDB entry 2fk4 coloured by chain, ensemble of 10 models, top view.
Source organism: Human papillomavirus type 16
Primary publication:
Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis.
Nominé Y, Masson M, Charbonnier S, Zanier K, Ristriani T, Deryckère F, Sibler AP, Desplancq D, Atkinson RA, Weiss E, Orfanoudakis G, Kieffer B, Travé G
Mol Cell 21 665-78 (2006)
PMID: 16507364

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136584 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein E6 Chain: A
Molecule details ›
Chain: A
Length: 75 amino acids
Theoretical weight: 8.91 KDa
Source organism: Human papillomavirus type 16
Expression system: Escherichia coli
UniProt:
  • Canonical: P03126 (Residues: 87-158; Coverage: 46%)
Gene name: E6
Sequence domains: Early Protein (E6)
Structure domains: E6 early regulatory protein

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, protocol refine.inp
Expression system: Escherichia coli

Quick links

Citations

42 review citations

Human papillomavirus molecular biology and disease association.
Doorbar et al. (2015)
41 more

8 mentions without citation

Evolution of human papillomavirus carcinogenicity.
Van Doorslaer et al. (2010)
7 more