› 2fnp

X-ray diffraction
2.6Å resolution

Crystal structure of SarA

Released:
DOI: 10.2210/pdb2fnp/pdb
PDB entry 2fnp coloured by chain, front view.
PDB entry 2fnp coloured by chain, side view.
PDB entry 2fnp coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus.
Liu Y, Manna AC, Pan CH, Kriksunov IA, Thiel DJ, Cheung AL, Zhang G
Proc Natl Acad Sci U S A 103 2392-7 (2006)
PMID: 16455801

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional regulator SarA Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.78 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7A1N5 (Residues: 1-124; Coverage: 100%)
Gene names: MW0580, sarA
Sequence domains: Winged helix DNA-binding domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 52.074Å b: 64.758Å c: 55.564Å
α: 90° β: 117.73° γ: 90°
R-values:
R R work R free
0.285 0.285 0.308
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

Pathogenicity and virulence of Staphylococcus aureus.
Cheung et al. (2021)
7 more

8 mentions without citation

Limitations and lessons in the use of X-ray structural information in drug design.
Davis et al. (2008)
7 more