› 2ftz

X-ray diffraction
1.9Å resolution

Crystal structure of Geranyltranstransferase (EC 2.5.1.10) (tm0161) from THERMOTOGA MARITIMA at 1.90 A resolution

Released:
DOI: 10.2210/pdb2ftz/pdb
PDB entry 2ftz coloured by chain, front view.
PDB entry 2ftz coloured by chain, side view.
PDB entry 2ftz coloured by chain, top view.
Source organism: Thermotoga maritima MSB8
Entry author: Joint Center for Structural Genomics (JCSG)

Function and Biology Details

Reaction catalysed: 
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194451 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Geranyltranstransferase Chain: A
Molecule details ›
Chain: A
Length: 284 amino acids
Theoretical weight: 33.18 KDa
Source organism: Thermotoga maritima MSB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WY08 (Residues: 1-272; Coverage: 100%)
Gene name: TM_0161
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

2 bound ligands:
Ligand UNL 2 x UNL
Ligand EDO 10 x EDO
1 modified residue:
Ligand MLY 24 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P43212
Unit cell:
a: 138.594Å b: 138.594Å c: 46.466Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.169 0.203
Expression system: Escherichia coli

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