› 2fv7

X-ray diffraction
2.1Å resolution

Crystal structure of human ribokinase

Released:
DOI: 10.2210/pdb2fv7/pdb
PDB entry 2fv7 coloured by chain, front view.
PDB entry 2fv7 coloured by chain, side view.
PDB entry 2fv7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rabeh WM, Tempel W, Nedyalkova L, Arrowsmith C, Edwards A, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + D-ribose = ADP + D-ribose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribokinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 35.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H477 (Residues: 11-322; Coverage: 97%)
Gene names: RBKS, RBSK
Sequence domains: pfkB family carbohydrate kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

4 bound ligands:
Ligand NA 2 x NA
Ligand MG 2 x MG
Ligand ADP 2 x ADP
Ligand UNX 12 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 45.53Å b: 72.978Å c: 90.958Å
α: 90° β: 91.08° γ: 90°
R-values:
R R work R free
0.201 0.198 0.248
Expression system: Escherichia coli BL21(DE3)

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