› 2fvh

X-ray diffraction
1.8Å resolution

Crystal Structure of Rv1848, a Urease Gamma Subunit UreA (Urea amidohydrolase), from Mycobacterium Tuberculosis

Released:
DOI: 10.2210/pdb2fvh/pdb
PDB entry 2fvh coloured by chain, front view.
PDB entry 2fvh coloured by chain, side view.
PDB entry 2fvh coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Entry authors: Bursey EH, Yu M, TB Structural Genomics Consortium (TBSGC), Lekin T, Rupp B, Kim CY, Rho BS, Terwilliger TC

Function and Biology Details

Reaction catalysed: 
Urea + H(2)O = CO(2) + 2 NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161407 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urease subunit gamma Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 120 amino acids
Theoretical weight: 13.19 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WFE7 (Residues: 1-100; Coverage: 100%)
Gene names: MTCY359.25c, Rv1848, ureA
Sequence domains: Urease, gamma subunit
Structure domains: Urease, gamma-like subunit

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P6
Unit cell:
a: 109.988Å b: 109.988Å c: 40.873Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.184 0.229
Expression system: Escherichia coli BL21(DE3)

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