› 2fwu

Solution NMR

Second Ca2+ binding domain of the Na,Ca-exchanger (NCX1)

Released:
DOI: 10.2210/pdb2fwu/pdb
PDB entry 2fwu coloured by chain, ensemble of 20 models, front view.
PDB entry 2fwu coloured by chain, ensemble of 20 models, side view.
PDB entry 2fwu coloured by chain, ensemble of 20 models, top view.
Source organism: Canis lupus familiaris
Primary publication:
Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors.
Hilge M, Aelen J, Vuister GW
Mol Cell 22 15-25 (2006)
PMID: 16600866

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/calcium exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.82 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P23685 (Residues: 533-724; Coverage: 17%)
Gene names: NCX1, SLC8A1
Sequence domains: Calx-beta domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

26 review citations

The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium.
Brini et al. (2011)
25 more

4 mentions without citation

Structure-Based Function and Regulation of NCX Variants: Updates and Challenges.
Khananshvili D. (2022)
3 more