› 2fzl

X-ray diffraction
2.9Å resolution

Structure of C-terminal domain of Archaeoglobus fulgidus XPB

Released:
DOI: 10.2210/pdb2fzl/pdb
PDB entry 2fzl coloured by chain, front view.
PDB entry 2fzl coloured by chain, side view.
PDB entry 2fzl coloured by chain, top view.
Source organism: Archaeoglobus fulgidus
Primary publication:
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.
Fan L, Arvai AS, Cooper PK, Iwai S, Hanaoka F, Tainer JA
Mol Cell 22 27-37 (2006)
PMID: 16600867

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA 3'-5' translocase XPB Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 25.67 KDa
Source organism: Archaeoglobus fulgidus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O29889 (Residues: 237-434; Coverage: 44%)
Gene names: AF_0358, xpb
Sequence domains: Helicase conserved C-terminal domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1
Spacegroup: I4132
Unit cell:
a: 172.859Å b: 172.859Å c: 172.859Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.249 0.291
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

31 review citations

Nucleotide excision repair in eukaryotes.
Schärer OD. (2013)
30 more

6 mentions without citation

XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.
Fuss et al. (2011)
5 more